Lung bioavailability of generic and innovator salbutamol MDIs.
نویسندگان
چکیده
منابع مشابه
Lung bioavailability of generic and innovator salbutamol metered dose inhalers.
BACKGROUND The aim of this study was to determine whether significant differences exist in lung bioavailability between generic (Salamol, Salbulin) and innovator (Ventolin) formulations of inhaled salbutamol given by metered dose inhalers. METHODS Ten healthy volunteers of mean age 20.5 years with a forced expiratory volume in one second (FEV1) of 112.1% predicted were studied in a randomised...
متن کاملInvestigations of an optimal inhaler technique with the use of urinary salbutamol excretion as a measure of relative bioavailability to the lung.
BACKGROUND A simple non-invasive method, in which a urine sample is taken 30 minutes after drug administration, has previously been shown to be a measure of the relative bioavailability of salbutamol to the lungs. This technique has been used to determine an optimal inhaler technique with commercially available metered dose inhalers (MDI). METHODS Ten healthy subjects were trained in the use ...
متن کاملAvailability, price and affordability of asthma medicines in five Indian states.
SETTING States of Haryana, Karnataka, Maharashtra and Rajasthan, and Chennai (capital of Tamil Nadu State), India. OBJECTIVE To assess the availability, price and affordability of beclomethasone and salbutamol inhalers in five Indian states using a standardised methodology. DESIGN Data on the availability and price of two essential medicines for asthma, beclomethasone (50 microg/dose) and s...
متن کاملEffect of multiple actuations, delayed inhalation and antistatic treatment on the lung bioavailability of salbutamol via a spacer device.
BACKGROUND The aim of this study was to extend previous in vitro observations regarding the effects of multiple actuations of aerosols into spacer devices, delayed inhalation, and antistatic treatment of spacer devices on the amount of drug delivered for inhalation. An in vivo study of lung bioavailability of salbutamol from a large volume (Volumatic) spacer was conducted. METHODS Ten healthy...
متن کاملRelative bioavailability of salbutamol to the lung following inhalation using metered dose inhalation methods and spacer devices.
BACKGROUND Inhalation aids do not require coordination between actuation of a metered dose inhaler (MDI) with inspiration and reduce oropharyngeal impaction. The delivery of salbutamol to the lung and systemic availability following inhalation with three commonly used spacers and an open mouth technique have been evaluated using a simple noninvasive technique based on urinary excretion 30 minut...
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عنوان ژورنال:
- Thorax
دوره 51 6 شماره
صفحات -
تاریخ انتشار 1996